Sch9 partially mediates TORC1 signaling to control ribosomal RNA synthesis.
Identifieur interne : 001486 ( Main/Exploration ); précédent : 001485; suivant : 001487Sch9 partially mediates TORC1 signaling to control ribosomal RNA synthesis.
Auteurs : Yuehua Wei [États-Unis] ; X F Steven ZhengSource :
- Cell cycle (Georgetown, Tex.) [ 1551-4005 ] ; 2009.
Descripteurs français
- KwdFr :
- ARN de transfert (génétique), ARN ribosomique (biosynthèse), Activation de la transcription (génétique), Facteurs de transcription (génétique), Mutation (génétique), Phosphatidylinositol 3-kinases (génétique), Phosphatidylinositol 3-kinases (métabolisme), Protein-Serine-Threonine Kinases (génétique), Protein-Serine-Threonine Kinases (métabolisme), Protéines de Saccharomyces cerevisiae (génétique), Protéines de Saccharomyces cerevisiae (métabolisme), Protéines et peptides de signalisation intracellulaire (génétique), Protéines et peptides de signalisation intracellulaire (métabolisme), Protéines membranaires (génétique), Protéines membranaires (métabolisme), RNA polymerase I (génétique), Régulation de l'expression des gènes fongiques (génétique), Saccharomyces cerevisiae (génétique), Saccharomyces cerevisiae (métabolisme), Structures macromoléculaires (métabolisme), Transduction du signal (génétique).
- MESH :
- biosynthèse : ARN ribosomique.
- génétique : ARN de transfert, Activation de la transcription, Facteurs de transcription, Mutation, Phosphatidylinositol 3-kinases, Protein-Serine-Threonine Kinases, Protéines de Saccharomyces cerevisiae, Protéines et peptides de signalisation intracellulaire, Protéines membranaires, RNA polymerase I, Régulation de l'expression des gènes fongiques, Saccharomyces cerevisiae, Transduction du signal.
- métabolisme : Phosphatidylinositol 3-kinases, Protein-Serine-Threonine Kinases, Protéines de Saccharomyces cerevisiae, Protéines et peptides de signalisation intracellulaire, Protéines membranaires, Saccharomyces cerevisiae, Structures macromoléculaires.
English descriptors
- KwdEn :
- Gene Expression Regulation, Fungal (genetics), Intracellular Signaling Peptides and Proteins (genetics), Intracellular Signaling Peptides and Proteins (metabolism), Macromolecular Substances (metabolism), Membrane Proteins (genetics), Membrane Proteins (metabolism), Mutation (genetics), Phosphatidylinositol 3-Kinases (genetics), Phosphatidylinositol 3-Kinases (metabolism), Protein-Serine-Threonine Kinases (genetics), Protein-Serine-Threonine Kinases (metabolism), RNA Polymerase I (genetics), RNA, Ribosomal (biosynthesis), RNA, Transfer (genetics), Saccharomyces cerevisiae (genetics), Saccharomyces cerevisiae (metabolism), Saccharomyces cerevisiae Proteins (genetics), Saccharomyces cerevisiae Proteins (metabolism), Signal Transduction (genetics), Transcription Factors (genetics), Transcriptional Activation (genetics).
- MESH :
- chemical , biosynthesis : RNA, Ribosomal.
- chemical , genetics : Intracellular Signaling Peptides and Proteins, Membrane Proteins, Phosphatidylinositol 3-Kinases, Protein-Serine-Threonine Kinases, RNA Polymerase I, RNA, Transfer, Saccharomyces cerevisiae Proteins, Transcription Factors.
- genetics : Gene Expression Regulation, Fungal, Mutation, Saccharomyces cerevisiae, Signal Transduction, Transcriptional Activation.
- chemical , metabolism : Intracellular Signaling Peptides and Proteins, Macromolecular Substances, Membrane Proteins, Phosphatidylinositol 3-Kinases, Protein-Serine-Threonine Kinases, Saccharomyces cerevisiae, Saccharomyces cerevisiae Proteins.
Abstract
TORC1 is a central regulator of ribosomal RNA synthesis. Here we report that Sch9 partially mediates TORC1 signaling to regulate Pol I- and Pol III-dependent transcription. Mechanistically, Sch9 is involved in hyperphosphorylation and cytoplasmic localization of Maf1, and for optimal synthesis of rRNAs and tRNAs. Interestingly, sch9Delta does not affect Maf1 basal phosphorylation and nucleolar localization. In addition, TORC1 is still capable of regulating rRNAs and tRNAs in the absence of Sch9. Moreover, the hyperactive Sch9(2D3E) mutant does not confer significant rapamycin resistance in cell growth. Together, these observations indicate that Sch9 is involved in optimal regulation of ribosome biogenesis by TORC1, but is dispensable for the essential aspects of ribosome biogenesis and cell growth, suggesting that TORC1 controls cell growth through Sch9-dependent and independent mechanisms.
DOI: 10.4161/cc.8.24.10170
PubMed: 19823048
PubMed Central: PMC3023923
Affiliations:
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(genetics)</term><term>Membrane Proteins (metabolism)</term><term>Mutation (genetics)</term><term>Phosphatidylinositol 3-Kinases (genetics)</term><term>Phosphatidylinositol 3-Kinases (metabolism)</term><term>Protein-Serine-Threonine Kinases (genetics)</term><term>Protein-Serine-Threonine Kinases (metabolism)</term><term>RNA Polymerase I (genetics)</term><term>RNA, Ribosomal (biosynthesis)</term><term>RNA, Transfer (genetics)</term><term>Saccharomyces cerevisiae (genetics)</term><term>Saccharomyces cerevisiae (metabolism)</term><term>Saccharomyces cerevisiae Proteins (genetics)</term><term>Saccharomyces cerevisiae Proteins (metabolism)</term><term>Signal Transduction (genetics)</term><term>Transcription Factors (genetics)</term><term>Transcriptional Activation (genetics)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>ARN de transfert (génétique)</term><term>ARN ribosomique (biosynthèse)</term><term>Activation de la transcription (génétique)</term><term>Facteurs de transcription (génétique)</term><term>Mutation (génétique)</term><term>Phosphatidylinositol 3-kinases (génétique)</term><term>Phosphatidylinositol 3-kinases (métabolisme)</term><term>Protein-Serine-Threonine Kinases (génétique)</term><term>Protein-Serine-Threonine Kinases (métabolisme)</term><term>Protéines de Saccharomyces cerevisiae (génétique)</term><term>Protéines de Saccharomyces cerevisiae (métabolisme)</term><term>Protéines et peptides de signalisation intracellulaire (génétique)</term><term>Protéines et peptides de signalisation intracellulaire (métabolisme)</term><term>Protéines membranaires (génétique)</term><term>Protéines membranaires (métabolisme)</term><term>RNA polymerase I (génétique)</term><term>Régulation de l'expression des gènes fongiques (génétique)</term><term>Saccharomyces cerevisiae (génétique)</term><term>Saccharomyces cerevisiae (métabolisme)</term><term>Structures macromoléculaires (métabolisme)</term><term>Transduction du signal (génétique)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="biosynthesis" xml:lang="en"><term>RNA, Ribosomal</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Intracellular Signaling Peptides and Proteins</term><term>Membrane Proteins</term><term>Phosphatidylinositol 3-Kinases</term><term>Protein-Serine-Threonine Kinases</term><term>RNA Polymerase I</term><term>RNA, Transfer</term><term>Saccharomyces cerevisiae Proteins</term><term>Transcription Factors</term></keywords><keywords scheme="MESH" qualifier="biosynthèse" xml:lang="fr"><term>ARN ribosomique</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Gene Expression Regulation, Fungal</term><term>Mutation</term><term>Saccharomyces cerevisiae</term><term>Signal Transduction</term><term>Transcriptional Activation</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>ARN de transfert</term><term>Activation de la transcription</term><term>Facteurs de transcription</term><term>Mutation</term><term>Phosphatidylinositol 3-kinases</term><term>Protein-Serine-Threonine Kinases</term><term>Protéines de Saccharomyces cerevisiae</term><term>Protéines et peptides de signalisation intracellulaire</term><term>Protéines membranaires</term><term>RNA polymerase I</term><term>Régulation de l'expression des gènes fongiques</term><term>Saccharomyces cerevisiae</term><term>Transduction du signal</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Intracellular Signaling Peptides and Proteins</term><term>Macromolecular Substances</term><term>Membrane Proteins</term><term>Phosphatidylinositol 3-Kinases</term><term>Protein-Serine-Threonine Kinases</term><term>Saccharomyces cerevisiae</term><term>Saccharomyces cerevisiae Proteins</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Phosphatidylinositol 3-kinases</term><term>Protein-Serine-Threonine Kinases</term><term>Protéines de Saccharomyces cerevisiae</term><term>Protéines et peptides de signalisation intracellulaire</term><term>Protéines membranaires</term><term>Saccharomyces cerevisiae</term><term>Structures macromoléculaires</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">TORC1 is a central regulator of ribosomal RNA synthesis. Here we report that Sch9 partially mediates TORC1 signaling to regulate Pol I- and Pol III-dependent transcription. Mechanistically, Sch9 is involved in hyperphosphorylation and cytoplasmic localization of Maf1, and for optimal synthesis of rRNAs and tRNAs. Interestingly, sch9Delta does not affect Maf1 basal phosphorylation and nucleolar localization. In addition, TORC1 is still capable of regulating rRNAs and tRNAs in the absence of Sch9. Moreover, the hyperactive Sch9(2D3E) mutant does not confer significant rapamycin resistance in cell growth. Together, these observations indicate that Sch9 is involved in optimal regulation of ribosome biogenesis by TORC1, but is dispensable for the essential aspects of ribosome biogenesis and cell growth, suggesting that TORC1 controls cell growth through Sch9-dependent and independent mechanisms.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">19823048</PMID><DateCompleted><Year>2010</Year><Month>05</Month><Day>13</Day></DateCompleted><DateRevised><Year>2020</Year><Month>09</Month><Day>30</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1551-4005</ISSN><JournalIssue CitedMedium="Internet"><Volume>8</Volume><Issue>24</Issue><PubDate><Year>2009</Year><Month>Dec</Month><Day>15</Day></PubDate></JournalIssue><Title>Cell cycle (Georgetown, Tex.)</Title><ISOAbbreviation>Cell Cycle</ISOAbbreviation></Journal><ArticleTitle>Sch9 partially mediates TORC1 signaling to control ribosomal RNA synthesis.</ArticleTitle><Pagination><MedlinePgn>4085-90</MedlinePgn></Pagination><Abstract><AbstractText>TORC1 is a central regulator of ribosomal RNA synthesis. Here we report that Sch9 partially mediates TORC1 signaling to regulate Pol I- and Pol III-dependent transcription. Mechanistically, Sch9 is involved in hyperphosphorylation and cytoplasmic localization of Maf1, and for optimal synthesis of rRNAs and tRNAs. Interestingly, sch9Delta does not affect Maf1 basal phosphorylation and nucleolar localization. In addition, TORC1 is still capable of regulating rRNAs and tRNAs in the absence of Sch9. Moreover, the hyperactive Sch9(2D3E) mutant does not confer significant rapamycin resistance in cell growth. Together, these observations indicate that Sch9 is involved in optimal regulation of ribosome biogenesis by TORC1, but is dispensable for the essential aspects of ribosome biogenesis and cell growth, suggesting that TORC1 controls cell growth through Sch9-dependent and independent mechanisms.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Wei</LastName><ForeName>Yuehua</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>Graduate Program in Cellular and Molecular Pharmacology, UMDNJ-Robert Wood Johnson Medical School, Piscataway, NJ, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zheng</LastName><ForeName>X F Steven</ForeName><Initials>XF</Initials></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>R01 CA123391</GrantID><Acronym>CA</Acronym><Agency>NCI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R01 CA123391-05</GrantID><Acronym>CA</Acronym><Agency>NCI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R01-CA123391</GrantID><Acronym>CA</Acronym><Agency>NCI NIH HHS</Agency><Country>United States</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D052061">Research Support, N.I.H., Extramural</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2009</Year><Month>12</Month><Day>25</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Cell Cycle</MedlineTA><NlmUniqueID>101137841</NlmUniqueID><ISSNLinking>1551-4005</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D047908">Intracellular Signaling Peptides and Proteins</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="C515118">Kog1 protein, S 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UI="D012343">RNA, Transfer</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 2.7.1.-</RegistryNumber><NameOfSubstance UI="D019869">Phosphatidylinositol 3-Kinases</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 2.7.1.137</RegistryNumber><NameOfSubstance UI="C083324">TOR1 protein, S cerevisiae</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 2.7.11.1</RegistryNumber><NameOfSubstance UI="D017346">Protein-Serine-Threonine Kinases</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 2.7.11.1</RegistryNumber><NameOfSubstance UI="C530964">SCH9 protein, S cerevisiae</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 2.7.7.6</RegistryNumber><NameOfSubstance UI="D012318">RNA Polymerase I</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><CommentsCorrectionsList><CommentsCorrections RefType="CommentIn"><RefSource>Cell Cycle. 2009 Dec 15;8(24):4023-4</RefSource><PMID Version="1">19959933</PMID></CommentsCorrections><CommentsCorrections 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|wiki= Bois
|area= RapamycinFungusV1
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|clé= pubmed:19823048
|texte= Sch9 partially mediates TORC1 signaling to control ribosomal RNA synthesis.
}}
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